AFP Recombinant Rabbit Monoclonal Antibody (3H2L7)
货号：703094
规格：100 µg
价格：4737
产品类型：免疫组化一抗
品牌：Thermo Fisher
物种：小鼠
宿主：兔
抗体亚型：IgG
荧光染料：其它
| 类型: | 单抗 | 同型对照： | |
| 浓度： | 0.5 mg/mL | 用法： | 1:250(WB) |
产品详细信息This antibody is predicted to react with Rat, Pig, Monkey.Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.靶标信息AFP (Alpha Fetoprotein) is a major plasma protein produced by the yolk sac, intestinal tract and the liver during fetal life. AFP expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of AFP may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and AFP and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. AFP is found in monomeric, dimeric, and trimeric forms. AFP can also bind to copper ions, nickel ions, fatty acids and bilirubin. The level of AFP in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. High level of serum AFP has been identified in patients with hepatocellular carcinomas (HCC), teratoblastoma, colorectal cancer, pancreatic cancer, and germ cell neoplasms.
| 数据 |
| AFP Antibody (703094) in WBWestern blot analysis was performed on tissue extracts (30 µg lysate) of Mouse Placenta (Lane 1) and Mouse Lung (Lane 2). The blot was probed with Anti-Alpha-fetoprotein (Mouse) Recombinant Rabbit Monoclonal Antibody (Product # 703094, 1:250 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 1:4000 dilution). A ~68 kDa band corresponding to Alpha-fetoprotein was observed in the relevant tissue model tested. |
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